Why the study?
Do dual reuptake inhibitors incur lower rates of tachyphylaxis than SSRIs in patients with major depressive disorder?
Do dual reuptake inhibitors incur lower rates of tachyphylaxis than SSRIs in patients with major depressive disorder?
Dual reuptake inhibitors may be associated with lower rates of tachyphylaxis compared to SSRIs in patients with major depressive disorder.
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May support preferring dual reuptake inhibitors in MDD to limit tachyphylaxis; leaves open need for randomized confirmation.
Posternak et al. (2005) studied this question.
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