Key result
Patients with stable SSRI use experienced the lowest risk of relapse or recurrence of depression compared to other prescription patterns such as early discontinuation, switching, or upward titration.
Why the study?
Do different SSRI prescription patterns affect the risk of relapse or recurrence of depression in patients treated for depression?
Observational (n=7,293)
Do different SSRI prescription patterns affect the risk of relapse or recurrence of depression in patients treated for depression?
Stable SSRI prescription patterns consistent with guidelines are associated with the lowest risk of depression relapse or recurrence.
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Supports guideline-aligned stable SSRI continuation; hypothesis-generating without randomized confirmation of relapse reduction.
Claxton et al. (2000) conducted an observational in Depression (n=7,293). Stable SSRI use vs. Other SSRI prescription patterns (less than 120 days, switching/augmentation, upward titration) was evaluated on Relapse or recurrence of depression during the 18-month follow-up period. Patients with stable SSRI use experienced the lowest risk of relapse or recurrence of depression compared to other prescription patterns such as early discontinuation, switching, or upward titration.
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