Key result
Patients initiating therapy on sertraline or paroxetine were less likely than those on fluoxetine to have four or more prescriptions of their initial antidepressant within the first 6 months.
Why the study?
Does initial SSRI selection affect the subsequent pattern and duration of antidepressant use in depressed outpatients?
Population
1,034 depressed outpatients in the United States with a 'new' episode of antidepressant therapy
Comparison
Initial prescription of paroxetine, sertraline… vs Comparison between fluoxetine, sertraline, and…
Design
Cohort
Follow-up
6 months
Authors
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Initial SSRI selection may influence early persistence; leaves open causal effects on adherence versus confounding in observational data.
Observational (n=1,034)
Does initial SSRI selection affect the subsequent pattern and duration of antidepressant use in depressed outpatients?
Initial SSRI selection (fluoxetine vs sertraline/paroxetine) influences the duration and pattern of antidepressant use in the first 6 months of therapy.
Hylan et al. (1999) conducted an observational in Depression (n=1,034). Sertraline or paroxetine vs. Fluoxetine was evaluated on Four or more prescriptions of initial antidepressant within the first 6 months. Patients initiating therapy on sertraline or paroxetine were less likely than those on fluoxetine to have four or more prescriptions of their initial antidepressant within the first 6 months.
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