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August 19, 2016The British Journal of PsychiatryOpen Access

Initiation and duration of selective serotonin reuptake inhibitor prescribing over time: UK cohort study

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Population

7,025,802 individuals aged over 18 years registered with a general practice contributing to The Health…

Design

Cohort

Follow-up

1995 to 2012

Authors

RMRachel L McCreaUniversity College LondonCSCormac SammonGreater London AuthorityINIrwin NazarethDepartment of Health and Social Care

Discussion

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Implication

Longer SSRI durations may drive UK antidepressant increases; leaves open optimal episode length and outcome effects in real-world cohorts.

Structured PICO

P
Population
7,025,802 individuals aged over 18 years registered with a general practice contributing to The Health Improvement Network
I
Intervention
Selective serotonin reuptake inhibitors (SSRIs)
O
Outcome
Rate of initiation of SSRIs over time and changes over time in the duration of prescribing episodes

The overall increase in antidepressant dispensing in the UK is driven by longer treatment durations rather than increasing initiation rates, which have stabilized since 2001.

Cite This Study

McCrea et al. (2016) studied this question.

synapsesocial.com/papers/6a7fbbffa9500df4273e88cehttps://doi.org/10.1192/bjp.bp.115.166975
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