Key result
Patients with mild to moderate pulmonary fibrosis had significantly impaired right ventricular diastolic function compared to healthy controls (E/A ratio 0.85 vs 1.28; P=0.035).
Why the study?
Does mild to moderate pulmonary fibrosis impair cardiac function as assessed by MRI compared to healthy controls?
Case-Control (n=32)
Does mild to moderate pulmonary fibrosis impair cardiac function as assessed by MRI compared to healthy controls?
Patients with mild to moderate pulmonary fibrosis exhibit isolated right ventricular diastolic impairment on MRI, equivalent to 20 years of normal aging, despite preserved biventricular systolic and left ventricular diastolic function.
Answers are grounded in this paper and cite their sources.
May signal early RV diastolic impairment in pulmonary fibrosis; leaves open prognostic value and need for longitudinal validation.
PURPOSE: To detect abnormalities in cardiac function by using magnetic resonance (MR) imaging in patients with mild to moderate pulmonary fibrosis and to evaluate the relationship between pulmonary function and cardiac function. MATERIALS AND METHODS: Sixteen patients were compared with 16 sex- and age-matched healthy control subjects. Systolic function was assessed by using multisection multiphase cine MR imaging. Diastolic function was assessed with flow-sensitive MR imaging across the mitral and tricuspid valves. MR imaging results were compared with the severity of impairment in pulmonary function. RESULTS: Biventricular systolic function and left ventricular diastolic function were normal in patients, but right ventricular diastolic function was significantly impaired versus that of control subjects, with a ratio of peak flow during early diastolic (E) filling to peak flow during atrial contraction (A) of 0.85 +/- 0.40 versus 1.28 +/- 0.50 (P =.035). Biventricular E/A ratios were strongly correlated to age in patients and control subjects. The right ventricular E/A ratio in patients corresponded with values that are normally expected in people 20 years older. Diastolic left and right ventricular functions were significantly correlated with each other. There was no relationship between pulmonary function and cardiac function. CONCLUSION: Impairment of right ventricular diastolic function was found by using MR imaging in patients with mild to moderate pulmonary fibrosis, whereas left ventricular diastolic function and biventricular systolic function were preserved.
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Kroft et al. (2000) conducted a case-control in Mild to moderate pulmonary fibrosis (n=32). Mild to moderate pulmonary fibrosis vs. Healthy control subjects was evaluated on Right ventricular diastolic function (E/A ratio) (p=.035). Patients with mild to moderate pulmonary fibrosis had significantly impaired right ventricular diastolic function compared to healthy controls (E/A ratio 0.85 vs 1.28; P=0.035).
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