Key result
Hepatitis E virus relies on distinct entry mechanisms for its enveloped and nonenveloped forms, and interacts with various host factors that serve as potential targets for novel antiviral therapies.
Why the study?
Hepatitis E virus is the major cause of acute viral hepatitis worldwide, but the mechanisms of liver pathology and clinical disease remain poorly understood.
This review summarizes current understanding of HEV-host cell interactions to provide insight into the viral life cycle and potential therapeutic targets.
The molecular interplay between cellular host factors and viral proteins is a continuous process throughout the viral life cycle determining virus host range and pathogenesis. The hepatitis E virus (HEV) is a long-neglected RNA virus and the major causative agent of acute viral hepatitis in humans worldwide. However, the mechanisms of liver pathology and clinical disease remain poorly understood for HEV infection. This review summarizes our current understanding of HEV-host cell interactions and highlights experimental strategies and techniques to identify novel host components required for the viral life cycle as well as restriction factors. Understanding these interactions will provide insight into the viral life cycle of HEV and might further help to devise novel therapeutic strategies and antiviral targets.
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Wißing et al. (2020) conducted a review in Hepatitis E Virus (HEV) infection. Hepatitis E virus relies on distinct entry mechanisms for its enveloped and nonenveloped forms, and interacts with various host factors that serve as potential targets for novel antiviral therapies.
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