Key result
Familial hypercholesterolemia in children was associated with decreased segmental longitudinal deformation and increased Endothelin-1 and NO, with 2 FHC patients showing decreased global strain.
Why the study?
Cardiac morphology and myocardial function in children with familial hypercholesterolemia are poorly understood, despite the risk of premature atherosclerosis and coronary heart disease.
Are there differences in left ventricular longitudinal deformation and endothelial function between children with familial hypercholesterolemia and healthy controls?
Case-Control (n=59)
Are there differences in left ventricular longitudinal deformation and endothelial function between children with familial hypercholesterolemia and healthy controls?
Speckle-tracking echocardiography can identify subclinical decreases in segmental longitudinal deformation of the left ventricle in children with familial hypercholesterolemia, who also show signs of endothelial dysfunction.
Answers are grounded in this paper and cite their sources.
Speckle-tracking may detect subclinical segmental LV changes in children with FH; hypothesis-generating, should not yet change practice.
Background . Familial hypercholesterolemia (FHC) is accompanied by a significant increase in the level of low-density lipoprotein cholesterol in the blood . The relevance of early diagnosis and treatment is due to the risk of premature development of atherosclerosis . Coronary heart disease due to atherosclerosis of the coronary arteries occurs among FHC patients up to 30 years . Currently , cardiac morphology and myocardial function in children with FHC are poorly understood . Objective . To assess global , segmental longitudinal deformation of the left ventricle and endothelial function in children with familial hypercholesterolemia . Design and methods . The study involved 25 healthy children and 34 children with FHC. Endothelin-1 and NO were determined by enzyme immunoassay . Echocardiographic study was carried . Assessment of global and segmental longitudinal deformation of the left ventricle was carried out in 4-chamber apical , 3-chamber and 2-chamber projections . Results . There were no statistically significant differences in global longitudinal strain (GLD) between groups . Individual analysis showed that 2 patients with FHC had a decrease in GLD. There was a statistically significant decrease in parameters in FHC patients at the level of the basal and apical anterior-septal , basal lower segments . Endothelin-1 and NO were increased in FHC compared to the control group . Conclusion . Speckle-tracking echocardiography allowed identifying patients with a decrease in global and segmental longitudinal deformation of the left ventricle among children with FHC.
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Galimova et al. (2022) conducted a case-control in Familial hypercholesterolemia (n=59). Familial hypercholesterolemia vs. Healthy children was evaluated on Global and segmental longitudinal deformation of the left ventricle and endothelial function. Familial hypercholesterolemia in children was associated with decreased segmental longitudinal deformation and increased Endothelin-1 and NO, with 2 FHC patients showing decreased global strain.
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