Key result
Viral modulation of RNA granules supports productive infection by inhibiting their gene-silencing functions and counteracting their role in linking stress sensing with innate immune activation.
Design
Review
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May guide antiviral development targeting RNA granule pathways; leaves open clinical translation in human infections.
Understanding viral manipulation of cytoplasmic RNA granules provides insight into mechanisms of viral replication and evasion of innate immunity.
Tsai et al. (2014) conducted a review in Viral infection. Viral infection was evaluated. Viral modulation of RNA granules supports productive infection by inhibiting their gene-silencing functions and counteracting their role in linking stress sensing with innate immune activation.
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