Key result
Triple therapy with aspirin, clopidogrel, and apixaban led to complete resolution of coronary occlusion and thrombus in two men with coronary artery ectasia and acute coronary syndrome.
Why the study?
Does triple therapy with DAPT and apixaban improve angiographic outcomes in patients with coronary artery ectasia presenting as acute coronary syndrome?
Case Report (n=2)
Does triple therapy with DAPT and apixaban improve angiographic outcomes in patients with coronary artery ectasia presenting as acute coronary syndrome?
Triple therapy including a NOAC (apixaban) and DAPT may be effective for resolving thrombus in patients with coronary artery ectasia presenting with acute coronary syndrome.
Coronary artery ectasia (CAE) is an abnormal dilatation of coronary artery segments, often linked with atherosclerosis. This report discusses two cases of CAE presenting as acute coronary syndrome. A 36-year-old man had proximal blockage in the left circumflex artery (LCx) and ectasia in the obtuse marginal artery and left anterior descending artery (LAD), while a 53-year-old male smoker had an ectatic LAD with a substantial thrombus. Both were treated with dual antiplatelet therapy (aspirin and clopidogrel) and non-vitamin K antagonist oral anticoagulants (NOACs), specifically apixaban, along with atorvastatin. The first patient had complete resolution of LCx occlusion after 1 year, and the second patient had complete thrombus dissolution in the LAD in 2 months. These cases highlight the potential benefits of NOACs in managing CAE in acute coronary syndrome, suggesting that triple therapy can significantly improve clinical outcomes.
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Izraiq et al. (2024) conducted a case report in Coronary artery ectasia in acute coronary syndrome (n=2). Triple therapy (aspirin, clopidogrel, and apixaban) with atorvastatin was evaluated on Resolution of occlusion or thrombus. Triple therapy with aspirin, clopidogrel, and apixaban led to complete resolution of coronary occlusion and thrombus in two men with coronary artery ectasia and acute coronary syndrome.
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