Key result
Exogenous poly(A) stimulated translation of capped, nonpolyadenylated mRNA in vitro, demonstrating that mRNA circularization per se is not the cause of cap-poly(A) synergy.
This study demonstrates that mRNA circularization per se is not the cause of cap-poly(A) synergy in vitro.
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Challenges circularization model of cap-poly(A) synergy; leaves open alternative mechanisms for mRNA translation studies.
Borman et al. (2002) studied this question. Exogenous poly(A) vs. Absence of exogenous poly(A) was evaluated on Translation of capped, nonpolyadenylated mRNA. Exogenous poly(A) stimulated translation of capped, nonpolyadenylated mRNA in vitro, demonstrating that mRNA circularization per se is not the cause of cap-poly(A) synergy.
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