Magnetic Nanoparticle Hyperthermia Using Pluronic‐Coated Fe3O4 Nanoparticles: An In Vitro Study

Magnetic nanoparticles are promising materials for hyperthermia treatment. The temperature rise under ac magnetic field, cytotoxicity, and in vitro hyperthermia effect of Fe3O4 nanoparticles coated with Pluronic f‐127 were evaluated in this paper. The Pluronic‐coated Fe3O4 nanoparticles exhibited no cytotoxic effect on HeLa cells. The optimal magnetic field of Pluronic‐coated Fe3O4 nanoparticles was 16 kA/m (200 Oe) at the field strength of 210 kHz. Appropriate temperature rise significantly reduced the viability of HeLa cells and induced apoptosis.