Key result
Glucagon (0.3 mg IV) decreased dominant gastric slow wave frequencies from 2.96 to 1.40 cpm (P<0.01) and elicited regional power reductions.
Why the study?
Does glucagon alter gastric slow wave frequency and power in healthy humans?
Population
12 healthy volunteers undergoing gastroscopy with midazolam
Comparison
Glucagon and endoscopic mucosal mapping vs Control conditions (baseline)
Design
Other
Authors
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Glucagon may suppress gastric slow waves in healthy subjects; hypothesis-generating for motility disorders and requires prospective validation.
Does glucagon alter gastric slow wave frequency and power in healthy humans?
Absolute Event Rate: 1.4% vs 2.96%
p-value: p=<0.01
Endoscopic mucosal mapping demonstrates that glucagon evokes bradygastria and regional inhibitory effects on gastric slow wave power.
Coleski et al. (2004) studied Healthy (n=12). Glucagon vs. Control conditions was evaluated on Dominant frequencies of gastric slow waves (p=<0.01). Glucagon (0.3 mg IV) decreased dominant gastric slow wave frequencies from 2.96 to 1.40 cpm (P<0.01) and elicited regional power reductions.
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