What question did this study set out to answer?

To examine the cellular origin and electrophysiological properties of spontaneous unitary potentials in circular muscle bundles of the gastric fundus.

June 25, 2004The Journal of Physiology

Properties of unitary potentials generated by intramuscular interstitial cells of Cajal in the murine and guinea‐pig gastric fundus

View Full Paper

Ask AI

Bookmark

Authors

EBElizabeth A. H. BeckettUniversity of Nevada, Reno YBY. R. BayguinovUniversity of Nevada, Reno KSKerrie M. SandersThe University of Melbourne

Discussion

Member takes

Implication

Electrophysiological study uncovers calcium-dependent unitary potentials driven by interstitial cells in rodent gastric fundus, explaining absent rhythmic electrical activity.

Key Points

To examine the cellular origin and electrophysiological properties of spontaneous unitary potentials in circular muscle bundles of the gastric fundus.
Obtained intracellular recordings from isolated circular muscle bundles of mouse and guinea-pig gastric fundus and antrum.
Compared electrical activity in wild-type tissues against mutant W/W(V) mice lacking intramuscular interstitial cells of Cajal (ICC(IM)).
Tested electrical responses following membrane potential shifts, chloride channel blockers, intracellular calcium buffering, and the mitochondrial uncoupler CCCP.
Spontaneous membrane noise was present in wild-type gastric fundus but completely absent in ICC(IM)-deficient W/W(V) mice.
Membrane noise frequency and amplitude showed negligible sensitivity to membrane depolarizing or hyperpolarizing current pulses and chloride channel blockers.
Intracellular calcium buffering and CCCP-mediated disruption of mitochondrial calcium uptake significantly reduced membrane noise while CCCP simultaneously induced membrane hyperpolarization.

Cite This Study

Beckett et al. (2004) studied this question.

synapsesocial.com/papers/6a94473a3c3b3bc8ec6d3447 https://doi.org/10.1113/jphysiol.2004.063016

View Full Paper

Ask AI

Bookmark

Implication

Electrophysiological study uncovers calcium-dependent unitary potentials driven by interstitial cells in rodent gastric fundus, explaining absent rhythmic electrical activity.

Properties of unitary potentials generated by intramuscular interstitial cells of Cajal in the murine and guinea‐pig gastric fundus

Discussion

Member takes

Implication

Key Points

Cite This Study

Properties of unitary potentials generated by intramuscular interstitial cells of Cajal in the murine and guinea‐pig gastric fundus

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider