Key result
In guinea-pig gastric antrum circular muscles, the frequency of slow potentials is correlated with internal Ca2+ concentration and coupled to Ca2+ release from internal stores.
Population
Isolated circular smooth muscle bundles of the guinea-pig gastric antrum
Design
Preclinical
Authors
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No immediate clinical application in gastric disorders; leaves open mechanistic roles of Ca2+ stores in human antral pacemaking.
In guinea-pig gastric antrum circular muscles, slow potentials are coupled to internal calcium release and modulated by mitochondrial ATP-sensitive K+ channels.
Fukuta et al. (2002) studied this question. Pharmacological agents (Nifedipine, Caffeine, BAPTA-AM, etc.) was evaluated on Spontaneous electrical activity and internal Ca(2+) concentration. In guinea-pig gastric antrum circular muscles, the frequency of slow potentials is correlated with internal Ca2+ concentration and coupled to Ca2+ release from internal stores.
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