Key result
QTc interval was an independent risk factor for non-dipper (OR 1.049; 95% CI 1.01-1.089) and reverse-dipper (OR 1.051; 95% CI 1.007-1.098) BP patterns in young/middle-aged hypertensive patients.
Why the study?
The relationship between electrocardiographic evaluation and circadian blood pressure variation in young and middle-aged hypertensive patients remains unknown.
Does QTc interval predict non-dipper and reverse-dipper blood pressure patterns in young and middle-aged hypertensive patients?
Observational (n=171)
Does QTc interval predict non-dipper and reverse-dipper blood pressure patterns in young and middle-aged hypertensive patients?
Odds Ratio: 1.049 (95% CI 1.01–1.089)
p-value: p=0.012
Prolonged QTc interval is independently associated with abnormal circadian blood pressure patterns (non-dipping and reverse-dipping) in young and middle-aged hypertensive patients.
Should not yet change practice; leaves open whether QTc predicts outcomes or warrants intervention in hypertension.
BACKGROUND: The relationship between electrocardiographic evaluation and circadian blood pressure (BP) variation in young and middle-aged hypertensive patients remains unknown. METHODS: A total of 171 hypertensive patients were included in the study. First, patients were divided into a young and middle-aged group and an elderly group. The two groups were then separately classified into three subgroups on the basis of circadian variation of BP as dippers, non-dippers and reverse-dippers. The electrocardiographic evaluation was calculated from 12-lead electrocardiography (ECG). RESULTS: QTc intervals were shortest in the dippers and longest in the reverse-dippers in the young and middle-aged group (QTc dipper: 416.53±18.37ms; non-dipper: 438.30±29.71ms; reverse-dipper: 444.93±25.47ms; for dipper vs non-dipper, and dipper vs reverse-dipper P<0.05). QTc interval was found to be an independent risk factor for the non-dipper BP pattern (Odds ratio 1.049; 95% CI 1.01-1.089; P=0.012) and reverse-dipper BP pattern (Odds ratio 1.051; 95% CI 1.007-1.098; P=0.023) in young and middle-aged hypertensive patients. No significant differences in other ECG parameters were found among the three subgroups in the young and middle-aged group. CONCLUSION: Our study suggested that QTc interval might serve as a risk factor for non-dipper BP pattern and reverse-dipper BP pattern in young and middle-aged hypertensive patients.
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Yan et al. (2020) conducted an observational in Hypertension (n=171). QTc interval was evaluated on Non-dipper blood pressure pattern (OR 1.049, 95% CI 1.01-1.089, p=0.012). QTc interval was an independent risk factor for non-dipper (OR 1.049; 95% CI 1.01-1.089) and reverse-dipper (OR 1.051; 95% CI 1.007-1.098) BP patterns in young/middle-aged hypertensive patients.
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