QT-corrected interval dispersion ≥45 ms was an independent predictor of major cardiovascular events compared to <45 ms (43% vs 11%; OR 4.9; 95% CI 2.0-12.1; P=0.001).
Cohort (n=108)
Does QT-corrected interval dispersion (QTcD) ≥45 ms predict major cardiovascular events in elderly hypertensive and normotensive patients?
QT-corrected interval dispersion ≥45 ms is an independent predictor of major cardiovascular events in elderly hypertensive and normotensive patients, suggesting its utility in risk stratification.
Effect estimate: OR 4.9 (95% CI 2.0-12.1)
Absolute Event Rate: 43% vs 11%
p-value: p=0.001
BACKGROUND: QT-corrected interval dispersion (QTcD) is an indirect index of increased heterogeneity of ventricular repolarization. However, the prognostic value of (QTcD) in elderly hypertensive and normotensive patients has not been thoroughly investigated yet. METHODS: The study population consisted of 60 consecutive patients (34 males/26 females; mean age: 63+/-11 years) with mild to moderate essential arterial hypertension and 48 consecutive age-matched healthy subjects (24 males/24 females; 65+/-16 years). QTcD was measured by a 12-lead electrocardiogram (ECG) as the difference between maximum and minimum QT-interval, corrected for heart rate. Ventricular arrhythmias were recorded by a 24-hour Holter ECG and classified by a modified Lown's score (range: 0-6). Left ventricular mass was measured echocardiographically and indexed by body surface area left ventricular mass index (LVMI). Nine patients were lost during the follow-up period. Patients were followed up for 54+/-9 months, and the primary end-point was the major cardiovascular events (including cardiac mortality). RESULTS: Major cardiovascular events occurred in 22 patients (22%). Patients with QTcD>or=45 ms (n=35) had a higher rate of major cardiovascular events (43% vs 11%; log rank: 14.8; Por=oror=oror=oror=or<437 ms). CONCLUSIONS: QTcD is an independent predictor of major cardiovascular events in elderly hypertensive and normotensive patients and might be used in their risk stratification.
Dimopoulos et al. (Thu,) conducted a cohort in Mild to moderate essential arterial hypertension and normotension (n=108). QTcD ≥45 ms vs. QTcD <45 ms was evaluated on Major cardiovascular events (including cardiac mortality) (OR 4.9, 95% CI 2.0-12.1, p=0.001). QT-corrected interval dispersion ≥45 ms was an independent predictor of major cardiovascular events compared to <45 ms (43% vs 11%; OR 4.9; 95% CI 2.0-12.1; P=0.001).
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