Key result
Higher common carotid artery end-diastolic velocity was independently associated with a reduced risk of future cerebro-cardiovascular events (HR 0.95 per cm/s) in asymptomatic high-risk patients.
Why the study?
Does common carotid artery end-diastolic velocity (CCA-EDV) predict future cerebro-cardiovascular events in asymptomatic patients at high risk for CAD?
Population
1,119 asymptomatic patients with risk factors for, but without, overt coronary artery disease or stroke…
Design
Cohort, Study coordinator blinded to carotid Doppler data during clinical data…
Follow-up
mean 1386±461 days
Authors
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Supports CCA-EDV as incremental prognostic marker beyond IMT/plaque; leaves open its role in guiding therapy for high-risk patients.
Cohort (n=1,119)
No
Does common carotid artery end-diastolic velocity (CCA-EDV) predict future cerebro-cardiovascular events in asymptomatic patients at high risk for CAD?
Hazard Ratio: 0.95 (95% CI 0.91–0.99)
p-value: p=0.034
Lower common carotid artery end-diastolic velocity provides incremental prognostic value beyond traditional risk factors, carotid IMT, and plaque for predicting cerebro-cardiovascular events in asymptomatic high-risk patients.
Chung et al. (2016) conducted a cohort in Asymptomatic patients at risk for coronary artery disease (n=1,119). Common carotid artery end-diastolic velocity was evaluated on All-cause cerebro-cardiovascular events (acute myocardial infarction, coronary revascularization therapy, heart failure admission, stroke, and cardiovascular death) (HR 0.95, 95% CI 0.91-0.99, p=0.034). Higher common carotid artery end-diastolic velocity was independently associated with a reduced risk of future cerebro-cardiovascular events (HR 0.95 per cm/s) in asymptomatic high-risk patients.
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