Pneumococcal Pneumonia Treated with Aqueous Penicillin at Twelve-Hour Intervals

The efficacy of penicillin in the treatment of patients with pneumococcal lobar pneumonia is well established.1 , 2 However, the manner in which it may be employed to yield the best therapeutic results and with the least discomfort to the patient is still debated. It has been considered that to achieve maximum therapeutic response the blood concentration of penicillin must be maintained constantly at a level greater than the penicillin sensitivity of the particular organism.3 Because of this assumption penicillin has generally been administered either in aqueous solution at frequent intervals or in some repository form. On the other hand, it has . . .