Key result
In a case series of scrub typhus patients, 80% developed multiple organ dysfunction syndrome and ARDS, but all responded well to doxycycline treatment.
Why the study?
Scrub typhus is an important and widespread cause of acute febrile illness that can be diagnosed easily by serological assay.
Does Doxycycline effectively treat scrub typhus in patients with acute febrile illness?
Observational
Does Doxycycline effectively treat scrub typhus in patients with acute febrile illness?
Scrub typhus can present with severe complications like ARDS and MODS but responds well to doxycycline, highlighting the need for high clinical suspicion in acute febrile illness.
Alerts clinicians to frequent MODS in scrub typhus; case report leaves open generalizability and risk predictors.
Introduction: Scrub typhus is an important and widespread cause of acute febrile illness (AFI), which can be diagnosed easily by serological assay. Methods: All cases of AFI were sent for Scrub Typhus serology by rapid Enzyme Linked Immuno-Sorbent Assay (ELISA) method. Anyone found positive was admitted for further evaluation. Results: In this series 80 % had liver abnormality, 80 % had ARDS, 40 % had renal failure, 40 % had eschar and 80 % of them had MODS. Only 20 % had clinical features of encephalitis with MRI brain haemorrhagic transformation of infarct. All patients responded well to treatment with Doxycycline with hospitalization of around 7-10 days. Conclusion: This case series highlights the importance of keeping a high index of clinical suspicion to exclude scrub typhus in all AFI patients.
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Shukla et al. (2023) conducted an observational in Acute Febrile Illness (AFI) with Scrub Typhus. Scrub typhus infection was evaluated on Clinical features and complications. In a case series of scrub typhus patients, 80% developed multiple organ dysfunction syndrome and ARDS, but all responded well to doxycycline treatment.
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