Why the study?
Scrub typhus can lead to serious multiple organ involvement and death in the absence of treatment, requiring a high index of clinical suspicion.
Case Report (n=3)
No
Scrub typhus can present with atypical and severe manifestations such as acute kidney injury and atrial fibrillation, highlighting the need for a high index of suspicion and prompt empirical treatment with doxycycline.
May support empirical doxycycline for atypical scrub typhus with AKI or AF; case reports leave open prospective validation.
Scrub typhus is one of the leading causes of acute febrile illness in India. It is associated with rash and often an eschar, which responds dramatically to antibiotics. In some cases, it results in serious illness leading to multiple organ involvement and finally death. The various clinical manifestations of scrub typhus arise mainly due to systemic vasculitis, caused by direct effects of organism as well as exaggerated immune response. The disease course is often complicated, leading to mortality in the absence of treatment. Here, in this case series, we describe three cases depicting the typical manifestations which a patient of scrub typhus can present with highlighting the fact that high index of clinical suspicion is of utmost importance for this deadly disease.
No takes yet. Share an insight, caveat, or question.
Mohanty et al. (2019) conducted a case report in Scrub typhus (n=3). Doxycycline was evaluated on Clinical recovery.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: