Key result
DOXHCl loaded nanoformulations showed significant cytotoxic effects on MCF-7 breast cancer cell lines, with F-4 formulations demonstrating an IC50 of 1.98 mcg/ml compared to 2.2 mcg/ml for free drug.
Why the study?
This study aimed to evaluate DOXHCl loaded P(DLLA-CO:60:40) nanoformulations with a copolymer of F127 as a potential drug delivery system for cancer.
Does DOXHCl loaded P(DLLA-CO:60:40) nanoformulation improve cytotoxicity compared to free drug in MCF-7 breast cancer cell lines?
Does DOXHCl loaded P(DLLA-CO:60:40) nanoformulation improve cytotoxicity compared to free drug in MCF-7 breast cancer cell lines?
Absolute Event Rate: 1.98% vs 2.2%
Doxorubicin hydrochloride loaded P(DLLA-CO:60:40) nanoformulations demonstrate sustained drug release and significant cytotoxicity against MCF-7 breast cancer cells.
Supports further preclinical evaluation of doxorubicin nanoformulations; leaves open clinical translation in breast cancer.
This study aimed to evaluate DOXHCl loaded P(DLLA-CO:60:40) nanoformulations with a copolymer of F127 as a potential drug delivery system for cancer. DOX HCl was encapsulated in nanoformulations of Poly DL-lactic acid co castor oil 60:40, P(DLLA-CO:60:40) polymer with the copolymer/stabilizer Pluronic F127. The mean diameter of the cylindrical rod shape of the nanoformulation particles was 2482.4-2603.2 nm with an acceptable poly dispersibility of 0.29-0.33 and a smooth surface as visualized by DSC, SEM and XRD displayed that DOXHCl was present as an disordered crystalline or amorphous state in the nanoformulations. The nanoformulations showed a steady pattern of drug discharge for 24 hrs. F-3 and F-4 formulations had IC 50 values of 3.20.03 and 1.980.08 mcg/ml while the free drug inhibition concentration of IC 50 was 2.2 mcg/ml. The drug-loaded nanoformulations showed significant cytotoxic effects on MCF-7 breast cancer cell lines.
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Sreeharsha et al. (2021) studied Breast cancer. DOXHCl loaded P(DLLA-CO:60:40) nanoformulations with a copolymer of F127 vs. Free drug was evaluated on Cytotoxicity (IC 50 values) on MCF-7 breast cancer cell lines. DOXHCl loaded nanoformulations showed significant cytotoxic effects on MCF-7 breast cancer cell lines, with F-4 formulations demonstrating an IC50 of 1.98 mcg/ml compared to 2.2 mcg/ml for free drug.
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