Key result
Age-related reduction in middle cerebral artery blood flow velocity was more pronounced in patients with musculoskeletal disorders, while cerebral autoregulation remained stable at 17-25%.
Why the study?
How does surgical lengthening of stunted limbs affect age-related decline in cerebral blood flow velocity compared to healthy subjects?
Observational (n=60)
How does surgical lengthening of stunted limbs affect age-related decline in cerebral blood flow velocity compared to healthy subjects?
Age-related decline in cerebral blood flow velocity is more pronounced in patients with musculoskeletal disorders, which may reduce their tolerance to physical exercise due to cerebral autoregulation disorders.
Answers are grounded in this paper and cite their sources.
May indicate reduced exercise tolerance in musculoskeletal disorders; leaves open effects of limb-lengthening surgery on cerebral flow.
Goal. Determining the causes of age-related decrease of blood flow velocity (BFV) in the middle cerebral artery (MCA) in healthy subjects and in patients during surgical lengthening of stunted limbs. Methods. BFV in MCA was determined by transcranial Doppler. The analysis of the indicator in functional muscle sample of 30 healthy people 18-60 years old and 30 patients 3-62 years of lagging in the growth of one of the lower limbs in the course of its operational extension. As an indicator of cerebral autoregulation used swing changes BFV indicators during the second holding muscle functional test. Results. The age-related reduction in flow rate in the middle cerebral artery was more pronounced in patients with disorders of the musculoskeletal system. At the same time, the average value of the magnitude of blood flow velocity index changes during the functional test in healthy individuals older than 10 years, as well as in patients before treatment and during the fixation is stable (17-25 %). Conclusion. Age-related decline in the BFV at MCA is a prerequisite for the preservation of cerebral autoregulation. Disorders of cerebral autoregulation in patients undergoing distraction of limbs greatly reduces their tolerance to physical exercise.
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V. A. Schurov (2016) conducted an observational in Lagging growth of lower limbs (n=60). Disorders of the musculoskeletal system requiring surgical limb lengthening vs. Healthy subjects was evaluated on Age-related decrease of blood flow velocity in the middle cerebral artery and cerebral autoregulation. Age-related reduction in middle cerebral artery blood flow velocity was more pronounced in patients with musculoskeletal disorders, while cerebral autoregulation remained stable at 17-25%.
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