Key result
Inoculation with Ad5-pIFNalpha completely protected swine from foot-and-mouth disease when challenged 24 hours later, whereas control swine developed typical signs of the disease.
Why the study?
Does Ad5-pIFNalpha protect swine from foot-and-mouth disease virus infection?
Population
Swine challenged with foot-and-mouth disease virus (FMDV)
Comparison
Recombinant, replication-defective human… vs Control Ad5 virus lacking the IFN gene…
Design
Preclinical
Authors
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Offers rapid protection in swine model; leaves open translation to field use or other species.
Does Ad5-pIFNalpha protect swine from foot-and-mouth disease virus infection?
Adenovirus-mediated delivery of porcine IFN-alpha provides rapid and complete protection against foot-and-mouth disease in swine.
Chinsangaram et al. (2002) studied Foot-and-mouth disease. Ad5-pIFNalpha vs. Control Ad5 virus lacking the IFN gene was evaluated on Protection from foot-and-mouth disease (clinical signs and viremia). Inoculation with Ad5-pIFNalpha completely protected swine from foot-and-mouth disease when challenged 24 hours later, whereas control swine developed typical signs of the disease.
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