Key result
Participation in a 100 km ultra-marathon significantly increased median hs-TnT from 5 ng/L to 14 ng/L (p < 0.0001), with 66% of runners exceeding upper reference values.
Why the study?
Intensive and prolonged exercise causes elevated blood troponin, but the mechanisms and risk factors underlying troponin release remain ill-defined.
What factors correlate with the increase in cardiac troponin T after participation in a 100 km ultra-marathon in healthy volunteers?
Observational (n=18)
What factors correlate with the increase in cardiac troponin T after participation in a 100 km ultra-marathon in healthy volunteers?
Absolute Event Rate: 14% vs 5%
p-value: p=< 0.0001
Participation in a 100 km ultra-marathon leads to a modest but significant increase in hs-TnT, which correlates with mean lactate and changes in hs-CRP.
hs-TnT rises after ultra-marathons should not yet alter athlete management; leaves open correlates with lactate and inflammation for prospective study.
Background: Intensive and prolonged exercise leads to a rise of troponin concentration in blood. The mechanism responsible for troponin release during exercise remains ill-defined. The study aim was to search for risk factors of troponin increase after a prolonged endurance competition. Methods: The study included a group of 18 amateurs, healthy volunteers (median age 41.5 years, interquartile range – IQR 36–53 years, 83% male) who participated in a 100 km running ultra-marathon. Information on demographic characteristics, pre- and post-race heart rate, blood pressure, body composition and glucose, lactate (L), troponin T (hs-TnT) and C reactive protein (hs-CRP) concentration were obtained. Additionally, data on L and glucose levels every 9.2 km and fluid/food intakes during the race were collected. Results: There was a significant hs-TnT increase after the race exceeding upper reference values in 66% of runners (from 5 IQR 3–7 ng/L to 14 IQR 12–26 ng/L, p < 0.0001). None of the baseline parameters predicted a post-race hs-TnT increase. The only factors, correlating with changes of hs-TnT were mean L concentration during the race (rho = 0.52, p = 0.03) and change of hs-CRP concentration (rho = 0.59, p = 0.01). Conclusions: Participation in a 100 km ultra-marathon leads to a modest, but significant hs-TnT increase in the majority of runners. Among analysed parameters only mean lactate concentration during the race and change in hs-CRP correlated with troponin change.
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Małek et al. (2020) conducted an observational in Healthy volunteers (n=18). 100 km ultra-marathon vs. Pre-race baseline was evaluated on hs-TnT concentration (ng/L) (p=< 0.0001). Participation in a 100 km ultra-marathon significantly increased median hs-TnT from 5 ng/L to 14 ng/L (p < 0.0001), with 66% of runners exceeding upper reference values.
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