Key result
Inoculation with the pWRMHX plasmid DNA vaccine induced neutralizing antibodies to FMDV in swine, protecting 20% of the vaccinated animals from challenge.
Population
BHK cells, suckling mice, and swine
Design
Preclinical
Authors
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Supports DNA vaccine development for FMDV; leaves open translation to field efficacy in livestock.
A DNA vaccine candidate for foot-and-mouth disease lacking the cell binding site induced neutralizing antibodies and partial protection in swine.
Ward et al. (1997) studied Foot-and-mouth disease (FMD). pWRMHX plasmid DNA vaccine vs. pWRMHX-pol- was evaluated on Protection from challenge. Inoculation with the pWRMHX plasmid DNA vaccine induced neutralizing antibodies to FMDV in swine, protecting 20% of the vaccinated animals from challenge.
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