Key result
Specific ACE gene variants (rs1799752 D/D genotype) and haplotypes (DCG, DTG, DCA, DTA) were positively associated with diabetic nephropathy in Tunisian type 2 diabetic patients.
Why the study?
Are specific ACE gene variants and haplotypes associated with the risk of diabetic nephropathy in Tunisian type 2 diabetic patients?
Case-Control (n=917)
Are specific ACE gene variants and haplotypes associated with the risk of diabetic nephropathy in Tunisian type 2 diabetic patients?
Specific ACE gene variants and haplotypes are associated with the pathogenesis of diabetic nephropathy in Tunisian patients with type 2 diabetes.
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Supports ACE variant screening research in North African T2D; leaves open replication and clinical utility.
Ezzidi et al. (2009) conducted a case-control in Type 2 diabetic nephropathy (n=917). ACE gene variants (rs1799752, rs1800764, rs12449782) and haplotypes vs. Patients without nephropathy (DWN) or reference haplotypes was evaluated on Association with diabetic nephropathy. Specific ACE gene variants (rs1799752 D/D genotype) and haplotypes (DCG, DTG, DCA, DTA) were positively associated with diabetic nephropathy in Tunisian type 2 diabetic patients.
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