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Commentarysufficient to eliminate malignant cells.By increasing endogenous IFN-␥ synthesis, therapeutic Th1 vaccines could promote recovery from chronic viral or parasitic infections.In summary, immunostimulatory oligonucleotides are adjuvants that simplify Th1 induction in experimental sys-tems.Their applications in clinical immunology will depend on whether the data generated in murine models will be reproducible in humans and whether the side effects of cytokine overproduction will be acceptable.
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Carson et al. (1997) studied this question.
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