The main objective of this paper was to relate tardive dyskinesia to the total intake of neuroleptics. The data were based on a selected sample of geriatric patients, on accurate and complete information on chemotherapy, and on three neurological examinations. A 7-point rating scale was used to distinguish drug-induced from spurious motor abnormalities. Two statistical approaches demonstrated that the risk of oral dyskinesia increases with the exposure to neuroleptics.
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George E. Crane (1974) studied this question.
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