Key result
G1P[8] rotavirus strains from both Rotarix vaccinated and unvaccinated children exhibited a 1.4-17.3% genomic divergence from the vaccine strain.
Observational (n=4)
No
G1P[8] rotavirus strains causing acute gastroenteritis in both vaccinated and unvaccinated children in India show significant genomic divergence from the Rotarix vaccine strain.
May indicate Rotarix mismatch with circulating strains; leaves open need for updated vaccines in India.
G1P[8] rotaviruses are predominant in causing diarrheal infections in humans all over the world. This study reports the analysis of complete genomes of G1P[8] strains, two each recovered from Rotarix™ vaccine recipients and non-recipients hospitalized for acute gastroenteritis in Pune, western India. All four strains showed a genogroup-1 backbone with intra-genotypic diversity in the VP7 and VP4 gene segments and a homogeneous constellation of the internal gene segments. A divergence in the range of 1.4-17.3% from Rotarix™ vaccine strain was revealed by structural and non-structural genes of the strains at nucleotide and amino acid level. These data reflect ability of such G1P[8] strains to cause rotavirus infections in humans.
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Pradhan et al. (2017) conducted an observational in Acute gastroenteritis (n=4). Rotarix vaccine vs. Non-recipients was evaluated on Genomic divergence from Rotarix vaccine strain. G1P[8] rotavirus strains from both Rotarix vaccinated and unvaccinated children exhibited a 1.4-17.3% genomic divergence from the vaccine strain.
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