We report direct measurements of the intrinsic electrical characteristics of polynucleotides using a conducting-probe atomic-force microscope under vacuum. Poly(dA)⋅poly(dT) self-assemble a cross-interlaced network on mica, but poly(dG)⋅poly(dC) self-organize a uniform two-dimensional reticulated structure. Transport studies demonstrate that poly(dG)⋅poly(dC) can act as a semiconducting nanowire and show a better conductance than that in poly(dA)⋅poly(dT).
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Cai et al. (2000) studied this question.
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