Key result
Combining amino acid variation and r(1)-values with crystallographic structural data successfully predicted antigenically relevant areas on the surface of the foot-and-mouth disease virion.
The study provides a methodology combining genetic variation, neutralization data, and structural data to quickly predict antigenically relevant sites for FMDV field strains, aiding in vaccine strain selection.
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May inform FMDV vaccine strain selection; leaves open validation across field strains.
Maree et al. (2011) studied Foot-and-mouth disease virus (FMDV). Phylogenetic, genetic and antigenic analyses was evaluated on Antigenic disparity and prediction of antigenic sites. Combining amino acid variation and r(1)-values with crystallographic structural data successfully predicted antigenically relevant areas on the surface of the foot-and-mouth disease virion.
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