January 1, 2000Environmental and Molecular Mutagenesis
Genetic instability and atherosclerosis: can somatic mutations account for the development of cardiovascular diseases?
Key result
Somatic mutations and genetic instability are hypothesized to contribute to the development of atherosclerosis, sharing pathological mechanisms with carcinogenesis.
Design
Review
Authors
Discussion
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Implication
Hypothesis-generating for somatic mutations in atherosclerosis; leaves open any therapeutic targeting pending prospective studies.
PICO
P
Population
Atherosclerosis
E
Exposure / Comparator
Somatic mutations
This paper highlights the 'monoclonal' hypothesis of atherosclerosis, suggesting that somatic mutations and genetic instability may drive plaque formation similarly to carcinogenesis.
Cite This Study
Andreassi et al. (2000) conducted a review in Atherosclerosis. Somatic mutations was evaluated. Somatic mutations and genetic instability are hypothesized to contribute to the development of atherosclerosis, sharing pathological mechanisms with carcinogenesis.