Why the study?
Do patients with post-polio fatigue have different intramuscular metabolic responses to exercise compared to healthy controls?
Do patients with post-polio fatigue have different intramuscular metabolic responses to exercise compared to healthy controls?
Whole body fatigue experienced by polio survivors does not appear to be related to systemic metabolic abnormalities in skeletal muscle.
Answers are grounded in this paper and cite their sources.
Post-polio fatigue does not appear tied to intramuscular metabolic changes during exercise; leaves open non-metabolic mechanisms for targeted study.
Changes in high energy phosphates (HEP) and intramuscular pH during exercise were measured in 17 patients with post-polio fatigue and in 28 healthy controls using 31P magnetic resonance spectroscopy (MRS). Subjects performed a dynamic hand grip exercise at low and high intensity. Mean changes in the HEP and pH showed no significant differences between the groups, although the post-polio group's response was highly variable. Six patients showed evidence of a lower lactate accumulation during the high intensity exercise when compared with controls. These data suggest that the whole body fatigue experienced by polio survivors is not related to any systemic metabolic abnormality.
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Thompson et al. (1991) studied this question.
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