Key result
The proportion of early infantile meningitis among all admitted infants under 3 months of age increased significantly from 1.6% in 2008 to 3.1% in 2013.
Observational (n=162)
No
Early infantile meningitis, particularly viral meningitis, in full-term and previously healthy infants <3 months old increased significantly between 2008 and 2013 in Korea, with a seasonal peak shift to June.
May signal rising early infantile meningitis burden warranting vigilance; leaves open etiologic and preventive research needs.
Purpose: The characteristics of early infantile meningitis in full-term and previously healthy infants may differ from those in preterm or previously ill infants. However, full-term and previously healthy infant data remain scarce, and the recent trends are not well known. Method: Full-term and previously healthy infants (<3 months old) diagnosed with meningitis in our hospital between January 2008 and December 2013 were enrolled. We retrospectively reviewed their clinical and laboratory data. Results: A total of 162 full-term and early infants with meningitis (male, 55.6%; mean age, 45 days) were enrolled. Among them, 122 patients (75.3%) were diagnosed with viral meningitis (63 enterovirus-proven and 59 viral-suspected), and 40 patients (24.7%) were diagnosed with bacterial meningitis (18 bacteria-proven and 22 bacterialsuspected). The proportion of early infantile meningitis among all infants admitted (<3 months of age) increased significantly from 1.6% to 3.1%, and viral meningitis increased from 1.1% to 2.3% (P<0.01). Early infantile meningitis increased significantly at each 2-year interval. The seasonal viral meningitis peak shifted from July to June after 2012. Group B Streptococcus was the most common bacterial pathogen (88.9%) and usually caused late-onset meningitis (14 of 16). Coxsackie B viruses were most commonly isolated (59.3%) from the 54 patients with viral meningitis using available genotype data. Conclusion: Early infantile meningitis in previously healthy full-term infants (<3 months old) increased significantly between 2008 and 2013, and most cases were viral meningitis. The seasonal viral meningitis peak shifted from July to June after 2012.
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천경렬 et al. (2015) conducted an observational in Early infantile meningitis (n=162). Time period (2008-2013) vs. 2008 (baseline) was evaluated on Proportion of early infantile meningitis among all admitted infants <3 months old (p=<0.01). The proportion of early infantile meningitis among all admitted infants under 3 months of age increased significantly from 1.6% in 2008 to 3.1% in 2013.
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