Key result
Prior poliomyelitis was associated with a higher risk of experiencing two or more late symptoms, particularly among those with permanent muscular weakness.
Why the study?
Does a history of poliomyelitis increase the risk of developing symptoms related to late effects of poliomyelitis compared to persons without a history of poliomyelitis?
Observational (n=263)
Does a history of poliomyelitis increase the risk of developing symptoms related to late effects of poliomyelitis compared to persons without a history of poliomyelitis?
Patients with a history of poliomyelitis, particularly those with permanent muscular weakness, have a significantly higher risk of developing symptoms related to late effects of poliomyelitis compared to the general population.
Answers are grounded in this paper and cite their sources.
May support symptom monitoring in polio survivors with weakness; leaves open causal confirmation in prospective studies.
OBJECTIVE: To compare the risk of developing symptoms related to late effects of poliomyelitis between polio patients and persons of similar age and sex without history of poliomyelitis. MATERIAL AND METHODS: The study comprised information on 148 patients with prior poliomyelitis and 115 persons with no history of poliomyelitis. Information was obtained by questionnaire and analyzed by multiple logistic regression method. RESULTS: The risk of experiencing two or more symptoms was significantly higher among the polio patients than among the persons without history of poliomyelitis. The elevation in risk was less pronounced in the nonparalytic group (OR = 2.35; 95% CI = 0.92-5.97) than the group with permanent muscular weakness (OR = 8.84; 95% CI =4.32-18.09). CONCLUSIONS: Although symptoms defined in the PPS are unspecific and may occur in the general population, the risk for developing such symptoms are higher among the polio victims. The difference in risk among nonparalytic and paralytic patients may depend on the extent of motor neuron damage in the acute stage.
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Rekand et al. (2000) conducted an observational in Late effects of poliomyelitis (n=263). Prior poliomyelitis vs. No history of poliomyelitis was evaluated on Experiencing two or more symptoms related to late effects of poliomyelitis (OR 8.84, 95% CI 4.32-18.09). Prior poliomyelitis was associated with a higher risk of experiencing two or more late symptoms, particularly among those with permanent muscular weakness.
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