Hyperinsulineamia as Risk Factor for Early Breast Cancer Recurrence Linked to Hormone Receptors and Human Epidermal Growth Factor Receptor 2

Background: Hyperinsuliunemia is a condition with excess levels of circulating insulin in the blood among non-diabetics. Hyperinsuliunemia may increase breast cancer developing probability.Purpose: to investigate the role of hyperinsuliunemia in early recurrence in breast cancer by estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2).Methods: 50 patients with invasive breast cancer in stage II and III in age range 17 - 65 years, involved in this study and classified into five subtypes of ER, PR and HER2, and followed prospectively for 2 years from beginning treatment based on insulin serum levels. Results: In newly diagnosed patients the mean concentrations and standard deviation were (17.11 ± 10.17), while the insulin levels in the patients after chemotherapy treatment were (26.06 ± 15.69), when the tow means were compared by t. test the blood concentration of insulin was high significantly in patients as control (p > 0.001). Regarding hormone receptors and HER2, the insulin levels in ER−PR−HER2− and ER− PR−HER2+ increased significantly after chemotherapy (p = 0.005 and 0.047) respectively. 10 of triple negative breast cancer patients suffered recurrence.Conclusion: Hyperinsuliunemia and weight change after chemotherapy may consider as risk factors for breast cancer recurrence among patients with triple-negative breast cancer.