Key result
Serotonin administration in diabetic rats elevated ROS concentrations, decreased antioxidant enzyme activities, and increased cell surface area and BNP expression, suggesting cardiac hypertrophy.
Why the study?
Does serotonin administration promote reactive oxygen species production and cardiac hypertrophy in diabetic rats?
Does serotonin administration promote reactive oxygen species production and cardiac hypertrophy in diabetic rats?
Serotonin secretion in diabetes may contribute to diabetic complications, including cardiac hypertrophy, through enhanced reactive oxygen species production.
Suggests serotonin may drive ROS-mediated hypertrophy in diabetic rat hearts; hypothesis-generating and should not change practice.
Patients with diabetes mellitus (DM) develop tendencies toward heart disease. Hyperglycemia induces the release of serotonin from enterochromaffin cells (EC). Serotonin was observed to elevate reactive oxygen species (ROS) and downregulate antioxidant enzymes. As a result, elevated levels of serotonin could contribute to diabetic complications, including cardiac hypertrophy. In the present study, diabetes mellitus was induced in rats by alloxan administration; this was followed by the administration of serotonin to experimental animals. ROS, catalase (CAT), superoxide dismutase (SOD), B-type natriuretic peptide (BNP) expression, and histopathological assessments were performed. Elevated ROS concentrations and decreased antioxidant enzyme activities were detected. Further, we observed an increase in cell surface area and elevated BNP expression which suggests that events associated with cardiac hypertrophy were increased in serotonin-administered diabetic rats. We conclude that serotonin secretion in diabetes could contribute to diabetic complications, including cardiac hypertrophy, through enhanced ROS production.
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Ali et al. (2015) studied Diabetes mellitus (alloxan-induced in rats). Serotonin was evaluated on ROS concentrations, antioxidant enzyme activities, cell surface area, and BNP expression. Serotonin administration in diabetic rats elevated ROS concentrations, decreased antioxidant enzyme activities, and increased cell surface area and BNP expression, suggesting cardiac hypertrophy.
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