Key result
Higher peak postoperative BNP independently predicted worse physical function up to 2 years after primary CABG surgery (effect estimate -3.06 points; 95% CI -5.15 to -0.97; P=0.004).
Why the study?
Does increased peak postoperative BNP predict decreased longer-term physical function in patients undergoing primary CABG surgery?
Population
845 patients undergoing primary coronary artery bypass graft surgery with cardiopulmonary bypass, mean age…
Design
Cohort
Follow-up
up to 2 years
Authors
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May warrant closer functional surveillance after CABG in high-BNP patients; extends biomarker-outcome links but remains hypothesis-generating pending trials.
Cohort (n=845)
Yes
Does increased peak postoperative BNP predict decreased longer-term physical function in patients undergoing primary CABG surgery?
Mean Difference: -3.06 (95% CI -5.15–-0.97)
p-value: p=0.004
Increased peak postoperative BNP independently predicts worse long-term physical function up to 2 years after primary CABG surgery.
Fox et al. (2011) conducted a cohort in Primary coronary artery bypass graft (CABG) surgery (n=845). Peak postoperative B-type natriuretic peptide (BNP) was evaluated on Postoperative physical function (PF) scores 6 months through 2 years after CABG surgery (effect estimate -3.06, 95% CI -5.15 to -0.97, p=0.004). Higher peak postoperative BNP independently predicted worse physical function up to 2 years after primary CABG surgery (effect estimate -3.06 points; 95% CI -5.15 to -0.97; P=0.004).
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