Key result
Enterovirus RNA detection in the CNS was not associated with late functional deterioration in previous poliomyelitis or with motor neuron disease.
Why the study?
Is enterovirus infection of the central nervous system associated with late functional deterioration in previous poliomyelitis or motor neuron disease?
Case-Control
Is enterovirus infection of the central nervous system associated with late functional deterioration in previous poliomyelitis or motor neuron disease?
Enterovirus infection of the CNS does not appear to be associated with late functional deterioration in previous poliomyelitis or motor neuron disease.
No association in case-control study does not support enteroviral role in post-polio decline or MND; leaves open alternative mechanisms.
We have searched, using a sensitive nested-PCR, for enterovirus RNA in cerebrospinal fluid and post mortem central nervous system (CNS) tissue from patients with previous poliomyelitis with or without late functional deterioration, patients with motor neuron disease (MND), and control patients with other neurological disease or without neurological disease. Enterovirus RNA was detected in patients with previous poliomyelitis and MND, but also in control patients with and without neurological disease. Our results do not provide any evidence that such enterovirus infection is related to late functional deterioration in patients with previous poliomyelitis, which could be attributed to other medical conditions in most instances, and do not support the hypothesis that MND is associated with enterovirus infection of the CNS. Nucleotide sequence analysis of enterovirus RNA sequences detected indicated that enteroviruses detected were of the non-polio type.
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Muir et al. (1996) conducted a case-control in Previous poliomyelitis and motor neuron disease (MND). Enterovirus infection of the CNS vs. Control patients with or without other neurological disease was evaluated on Presence of enterovirus RNA in cerebrospinal fluid and post mortem CNS tissue. Enterovirus RNA detection in the CNS was not associated with late functional deterioration in previous poliomyelitis or with motor neuron disease.
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