Why the study?
Does enterovirus persist in the central nervous system of patients with previous paralytic poliomyelitis?
Population
Patients with previous paralytic poliomyelitis and controls with other neurological conditions of…
Comparison
Detection of enterovirus RNA sequences using… vs Patients with stable poliomyelitis and patients…
Design
Cross-sectional, Blind study (for the prospective cohort)
Authors
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Enteroviral RNA in post-polio syndrome CSF supports possible persistence; hypothesis-generating and should not yet change practice.
Does enterovirus persist in the central nervous system of patients with previous paralytic poliomyelitis?
This study provides virological evidence that enteroviruses may persist in the central nervous system of humans, potentially contributing to late-onset neurological deterioration after poliomyelitis.
Muir et al. (1995) studied this question.
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