Key result
Higher central augmentation index was significantly associated with abnormal language function (OR 1.14) and abnormal clock-drawing (OR 1.08) in adults over 50.
Why the study?
Are central blood pressure indices and arterial stiffness associated with mild cognitive impairment in adults over the age of 50?
Cross-Sectional (n=50)
Yes
Are central blood pressure indices and arterial stiffness associated with mild cognitive impairment in adults over the age of 50?
Central blood pressure indices, specifically augmentation index and pulse pressure amplification, are associated with deficits in executive function and language in older adults, suggesting they may serve as sensitive markers of cognitive decline.
Should not yet alter cognitive screening; leaves open whether central augmentation index predicts decline or informs intervention.
To determine the relationship between central blood pressure (CBP) indices and mild cognitive impairment (MCI) in adults over the age of 50. A cross-sectional study conducted using a non-invasive SphygmoCor XCEL device. CBP indices and brachial blood pressure were measured in 50 inpatients and outpatients. MCI was assessed using the Montreal Cognitive Assessment (MoCA) instrument and by the European Consortium Criteria (ECC). Seventy-six percent of subjects had hypertension, and 52% were diagnosed as having MCI using the ECC. No significant association was found between any of the measured blood pressure variables and global cognition. A significant relationship was observed between augmentation index (AI) and abnormal clock-drawing ( p = 0.04) and language ( p = 0.02), and between pulse pressure amplification (PPA) and language ( p = 0.03). CBP indices like AI and PPA, which are markers of vascular stiffness, are associated with poor executive function and language cognitive domain deficits.
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Suleman et al. (2017) conducted a cross-sectional in Mild cognitive impairment (n=50). Central blood pressure indices (Augmentation index and Pulse pressure amplification) was evaluated on Abnormal language score (associated with augmentation index) (OR 1.14, 95% CI 1.02-1.27, p=0.02). Higher central augmentation index was significantly associated with abnormal language function (OR 1.14) and abnormal clock-drawing (OR 1.08) in adults over 50.
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