Regional intra-arterial infusion chemotherapy combined with deep hyperthermia and targeted therapy followed by radiotherapy for recurrence with intestinal obstruction after radical resection of rectal cancer in an elderly patient: a case report of individualized treatment

The local recurrence rate after radical resection of rectal cancer is approximately 5%-20%, and can increase to 20%-35% in elderly patients who do not receive radiotherapy or chemotherapy. Recurrence is frequently complicated by intestinal obstruction, with a median survival of only 6-7 months. Herein, we report a case of an elderly patient who developed local recurrence with complete intestinal obstruction 4 months after radical resection of rectal cancer. After obstruction relief achieved by intestinal stent placement, a comprehensive treatment strategy was implemented based on genetic testing and multidisciplinary team discussion, consisting of regional intra-arterial infusion chemotherapy combined with deep hyperthermia and bevacizumab, followed by sequential radiotherapy. The patient ultimately achieved complete remission and long-term stable disease.