Nerve Degeneration in Poliomyelitis

The preceding papers of this series1dealt with a correlation between histologic evidence of degenerative changes in the roots and nerves supplying the affected extremities in experimental acute poliomyelitis and physiologic data concerning the concurrent dysfunction. The problem was undertaken with the view that the condition of the mensurable physiologic properties of the nerve fiber is the best index to the functional state of its cell of origin. For the functional aspect of the study the cathode ray oscillograph was employed to record the physiologic properties of the nerves and roots in vitro. In addition galvanic stimulation was applied: (1) to the cord above the segments supplying the affected extremity, and (2) to the roots and nerves during the preparalytic stage and at intervals subsequent to the onset of paralysis. Standard neurohistologic procedures were also employed. In order to interpret results, it was necessary to secure quantitative data concerning