Primary Acquired Hypogammaglobulinemia, Myasthenia, and Thymoma

Case Studies1 September 1966Primary Acquired Hypogammaglobulinemia, Myasthenia, and ThymomaK. TE VELDE, M.D., J. HUBER, M.D., L. B. VAN DER SLIKKE, M.D.K. TE VELDE, M.D.Search for more papers by this author, J. HUBER, M.D.Search for more papers by this author, L. B. VAN DER SLIKKE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-3-554 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe association of primary acquired hypogammaglobulinemia and a thymic tumor was first described by Good (1) in 1954. In 1960 Gafni, Michaeli, and Heller (2) reported on 2 patients with these two affections, and they traced in the literature among 44 patients with primary acquired hypogammaglobulinemia 4 combinations with thymoma (1, 3-5). Recently another four cases have been published (6-9), so that as far as we know a total of ten cases is known.The present paper is the case report of an adult woman, in whom primary acquired hypogammaglobulinemia developed 12 years after the discovery of a mediastinal tumor...References1. Good RA: Agammaglobulinemia—a provocative experiment of nature. Bull. Univ. Minnesota Hosp. Minnesota Med. Found. 26: 1, 1954. Google Scholar2. GAFNIMICHAELIHELLER JDH: Idiopathic acquired agammaglobulinemia associated with thymoma. Report of two cases and review of the literature. New Eng. J. Med. 263: 536, 1960. CrossrefMedlineGoogle Scholar3. MARTINGORDONMCGULLOUGH CMRSNB: Acquired hypogammaglobulinemia in an adult: report of a case with clinical and experimental studies. New Eng. J. Med. 254: 449, 1956. CrossrefMedlineGoogle Scholar4. RAMOS AJ: Presentation of a case, diagnostic problems. JAMA 160: 1317, 1956. CrossrefMedlineGoogle Scholar5. LAMBIEBURROWSSOMMERS ATASC: Clinico-pathologic conference; refractory anemia, agammaglobulinemia and mediastinal tumor. Amer. J. Clin. Path. 27: 444, 1957. CrossrefMedlineGoogle Scholar6. GODFREY S: Thymoma with hypogammaglobulinemia in an identical twin. Brit. Med. J. 1: 1159, 1964. CrossrefMedlineGoogle Scholar7. JACOXMONGANHANSHAWLEDDY RFESJBJP: Hypogammaglobulinemia with thymoma and probably pulmonary infection with cytomegalovirus. New Eng. J. Med. 271: 1091, 1964. CrossrefMedlineGoogle Scholar8. RUBINSTRAUSALLEN MBL: Clinical disorders associated with thymic tumors. Arch. Intern. Med. (Chicago) 114: 389, 1964. CrossrefMedlineGoogle Scholar9. JEUNET P: Thymoma et syndrome de carence en immunoglobulines. Scheiz. Med. Wschr. 43: 1419, 1965. Google Scholar10. RUSSCHEN CJ: A new method for quantitation of immune globulins, in Protides of the Biological Fluids, Proceedings of the XIVth Colloquium, Bruges, Belgium. In press, 1966. Google Scholar11. LATTES R: Thymoma and other tumours of the thymus. Cancer 15: 1224, 1962. CrossrefGoogle Scholar12. MACLEANZAKVARCOGOOD LDSJRLRA: Thymic tumor and acquired agammaglobulinemia—a clinical and experimental study of the immune response. Surgery 40: 1010, 1956. MedlineGoogle Scholar13. PORTER HM: Congenital agammaglobulinemia: a sex-linked genetic trait and demonstration of delayed skin sensitivity. Amer. J. Dis. Child. 90: 617, 1955. Google Scholar14. GELDFELTKAMPOOSTERHUIS HVTEHJ: Reactivity of myasthenia gravis serum gamma-globulin with skeletal muscle and thymus, demonstrated by immunofluorescence. Proc. Soc. Exp. Biol. Med. 115: 782, 1964. CrossrefMedlineGoogle Scholar15. GELDSTRAUS HWAJ: Myasthenia gravis. Lancet 1: 57, 1966. MedlineGoogle Scholar16. FISCHERBEYER ERFD: Thymoma and hemopoietic insufficiency. Arch. Intern. Med. (Chicago) 103: 95, 1959. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: K. TE VELDE, M.D.; J. HUBER, M.D.; L. B. VAN DER SLIKKE, M.D.Affiliations: Groningen,From the Departments of Medicine and Pathology, University of Groningen, The Netherlands.Requests for reprints should be addressed to K. te Velde, Department of Medicine, University Hospital, Oostersingel 59, Groningen, The Netherlands. 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