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September 1, 1999Nucleic Acids ResearchOpen Access

Visualization of double-stranded RNAs from the myotonic dystrophy protein kinase gene and interactions with CUG-binding protein

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Key result

Electron microscopy revealed that the DM expansion forms an RNA hairpin structure and CUG-BP localizes to the base of the hairpin, suggesting CUG-BP is unlikely to be a sequestered factor.

Authors

SMSusan MichalowskiUniversity of North Carolina at Chapel HillJMJ. W. MillerUniversity of FloridaCUCarl R. UrbinatiLoyola Marymount University

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Implication

Challenges CUG-BP sequestration in DM; leaves open alternative RNA mechanisms and requires validation before any clinical consideration.

PICO

P
Population
Myotonic dystrophy
E
Exposure / Comparator
CUG-binding protein (CUG-BP) and DMPK transcripts
O
Primary Outcome
RNA structure and CUG-BP binding properties

Cite This Study

Michalowski et al. (1999) studied Myotonic dystrophy. CUG-binding protein (CUG-BP) and DMPK transcripts was evaluated on RNA structure and CUG-BP binding properties. Electron microscopy revealed that the DM expansion forms an RNA hairpin structure and CUG-BP localizes to the base of the hairpin, suggesting CUG-BP is unlikely to be a sequestered factor.

synapsesocial.com/papers/6a9468d30fb6205a7ca0cea7https://doi.org/10.1093/nar/27.17.3534
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of a (CUG)n Triplet Repeat RNA-Binding Protein and Its Expression in Myotonic Dystrophy1996 · 469 citations
  2. 2Myotonic dystrophy: evidence for a possible dominant-negative RNA mutation1995 · 178 citations
  3. 3Triplet repeat expansion in myotonic dystrophy alters the adjacent chromatin structure.1995 · 191 citations