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PRV latency transcripts mapped in swine ganglia; leaves open their role in persistence and potential antiviral targets.
Two pseudorabies virus (PRV) poly(A)+ RNAs, 2.0 and 0.95 kilobases, were detected in the trigeminal ganglia of latently infected pigs. These RNAs were partially colinear at the 3' end. They were located in the BamHI J fragment (0.706 to 0.737 map units), 3' of the PRV immediate-early gene. A potential polyadenylation signal was also identified in BamHI-J. The direction of transcription of the latency-associated RNAs was antiparallel (i.e., opposite in polarity) to that of the PRV immediate-early mRNA.
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Andrew Cheung (1989) studied this question.
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