February 1, 1979Journal of VirologyOpen Access

Parental adenovirus type 2 genomes recovered early or late in infection possess terminal proteins

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Population

KB cells infected with adenovirus 2

Design

Preclinical

Follow-up

18 hours

Authors

Discussion

Persistent terminal protein linkage suggests essential role in adenovirus replication; leaves open validation as therapeutic target.

Population

KB cells infected with adenovirus 2

Intervention

Infection with adenovirus 2 and density shift experiments employing 5-bromo-2'-deoxyuridine

Outcome

Presence of terminally linked proteins on parental nuclear viral genomes at early (3 h) and late (18 h) times after infectionsurrogate

The persistent linkage of proteins to the termini of intranuclear viral DNA suggests these proteins have an essential role in adenovirus replication.

Straus et al. (1979) studied this question.

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