Key result
This review discusses the pharmacology, toxicities, and clinical trial evidence regarding the use of intravenous hydroxyethyl starch (HES) for fluid resuscitation in critically ill and surgical patients.
Why the study?
Does hydroxyethyl starch (HES) compared to crystalloids affect mortality and renal outcomes in critically ill and surgical patients?
Population
Critically ill and surgical patients requiring intravenous fluid resuscitation
Comparison
Hydroxyethyl starch (HES) solutions vs Crystalloids (e.g., saline, balanced fluids)
Design
Review
Authors
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HES should be avoided in septic ICU patients; leaves open its perioperative safety profile.
Does hydroxyethyl starch (HES) compared to crystalloids affect mortality and renal outcomes in critically ill and surgical patients?
The safety and efficacy of hydroxyethyl starch solutions appear highly context-dependent, with clear harms in septic ICU patients but debated risks in intraoperative settings.
Raghunathan et al. (2014) conducted a review in Hypovolemia and critical illness. Intravenous Hydroxyethyl Starch (HES) vs. Crystalloids or other fluids was evaluated. This review discusses the pharmacology, toxicities, and clinical trial evidence regarding the use of intravenous hydroxyethyl starch (HES) for fluid resuscitation in critically ill and surgical patients.
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