Effects of hyper- and hypoventilation on gastric and sublingual P CO 2

Q: What is the clinical evidence from this study?

Population: Hemorrhagic shock. Intervention: Hyper- and hypoventilation vs. Physiological conditions / absence of hyper- or hypoventilation. Primary outcome: Gastric and sublingual tissue PCO2.

Andrej Pernat; Max Harry Weil; Wanchun Tang; Hitoshi Yamaguchi; Andreja Marn Pernat; Shijie Sun; Joe Bisera

doi:10.1152/jappl.1999.87.3.933

September 1, 1999Journal of Applied Physiology

Effects of hyper- and hypoventilation on gastric and sublingual P CO 2

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Key result

Hyper- and hypoventilation produced corresponding decreases and increases in gastric and sublingual tissue PCO2 under physiological conditions and during hemorrhagic shock.

Why the study?

Does hyper- and hypoventilation affect gastric and sublingual PCO2 during hemorrhagic shock?

Key Points

To investigate how hyperventilation and hypoventilation affect gastric and sublingual tissue carbon dioxide partial pressures before, during, and after the reversal of hemorrhagic shock.
Evaluated tissue carbon dioxide partial pressures under physiological baseline conditions, during hemorrhagic shock, and following shock reversal.
Measured gastric carbon dioxide partial pressure using an ion-sensitive field-effect transistor sensor and sublingual carbon dioxide partial pressure with a carbon dioxide microelectrode across induced hyper- and hypoventilation states.
Hyperventilation-induced decreases and hypoventilation-induced increases in arterial and end-tidal carbon dioxide produced statistically similar decreases and increases in gastric and sublingual tissue carbon dioxide.
No significant changes were observed in the tissue-to-arterial carbon dioxide gradients during hemorrhagic shock, whether hyperventilation or hypoventilation was present or absent.

Structured PICO

Does hyper- and hypoventilation affect gastric and sublingual PCO2 during hemorrhagic shock?

P

Population

Subjects (likely animal model) undergoing hemorrhagic shock and reversal

I

Intervention

Hyperventilation and hypoventilation

C

Comparator

Physiological conditions (baseline)

O

Outcome

Gastric and sublingual tissue PCO2surrogate

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Implication

Acute changes in gastric and sublingual PCO2 should be interpreted in relationship with concurrent changes in arterial and/or end-tidal PCO2.

Abstract

We investigated the effects of hyper- and hypoventilation on gastric ([Formula: see text]) and sublingual (P[Formula: see text]) tissue[Formula: see text] before, during, and after reversal of hemorrhagic shock. [Formula: see text] was measured with ion-sensitive field-effect transistor sensor and P[Formula: see text] with a CO2 microelectrode. Under physiological conditions and during hemorrhagic shock, decreases in arterial ([Formula: see text]) and end-tidal ([Formula: see text])[Formula: see text] induced by hyperventilation produced corresponding decreases in[Formula: see text] and P[Formula: see text]. Hypoventilation produced corresponding increases in[Formula: see text],[Formula: see text],[Formula: see text], and P[Formula: see text]. Accordingly, acute decreases and increases in[Formula: see text] and[Formula: see text] produced statistically similar decreases and increases in[Formula: see text] and P[Formula: see text]. No significant changes in the tissue[Formula: see text]-[Formula: see text]gradients were observed during hemorrhagic shock in the absence or in the presence of hyper- or hypoventilation. Acute changes in[Formula: see text] and P[Formula: see text] should, therefore, be interpreted in relationship with concurrent changes in[Formula: see text] and/or[Formula: see text].

Discussion

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Cite This Study

Pernat et al. (1999) studied Hemorrhagic shock. Hyper- and hypoventilation vs. Physiological conditions / absence of hyper- or hypoventilation was evaluated on Gastric and sublingual tissue PCO2. Hyper- and hypoventilation produced corresponding decreases and increases in gastric and sublingual tissue PCO2 under physiological conditions and during hemorrhagic shock.

synapsesocial.com/papers/6a946a924ec1eb7af13edf7e https://doi.org/10.1152/jappl.1999.87.3.933

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Effects of hyper- and hypoventilation on gastric and sublingual P CO 2

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Effects of hyper- and hypoventilation on gastric and sublingual P CO 2

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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