October 1, 1993American Review of Respiratory Disease
Arteriovenous Differences in PCO2 and pH are Good Indicators of Critical Hypoperfusion
Why the study?
Do venoarterial PCO2 difference and arteriovenous pH difference indicate critical hypoperfusion as effectively as blood lactate during acute reduction in blood flow?
Population
13 anesthetized and mechanically ventilated dogs
Comparison
Acute reduction in blood flow induced by cardiac… vs Baseline state prior to cardiac tamponade
Design
Preclinical
Authors
Discussion
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Implication
VAPCO2 and AVpH may track critical hypoperfusion in experimental low-flow states; leaves open clinical utility versus lactate in human shock.
Structured PICO
Do venoarterial PCO2 difference and arteriovenous pH difference indicate critical hypoperfusion as effectively as blood lactate during acute reduction in blood flow?
P
Population
13 anesthetized and mechanically ventilated dogs
I
Intervention
Acute reduction in blood flow induced by cardiac tamponade via intrapericardial saline injection
C
Comparator
Baseline state prior to cardiac tamponade
O
Outcome
Changes in venoarterial difference in PCO2 (VAPCO2), arteriovenous difference in pH (AVpH), and blood lactate in relation to O2 delivery (DO2) and O2 uptake (VO2)surrogate
Venoarterial PCO2 difference and arteriovenous pH difference are reliable indicators of critical hypoperfusion, comparable to blood lactate, in a canine model of cardiac tamponade.
Cite This Study
Zhang et al. (1993) studied this question.